The Drug-Induced Respiratory Disease Website

Atorvastatin

Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

Although not mentioned in the paper, authors confirmed their patient developed OP while being treated with atorvastatin

Tzouvelekis A, Koutsopoulos A, Oikonomou A, Froudarakis M, Zarogoulidis P, Steiropoulos P, Mikroulis D, Antoniades A, Bouros D

Acute fibrinous and organising pneumonia: a case report and review of the literature.

Journal of medical case reports 2009 Oct 12;3;74 — 2009 Oct 12 — 74

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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