The Drug-Induced Respiratory Disease Website

Anticoagulants, oral (vitamin K antagonists-VKA)

Pulmonary hematoma

(Fr: hématome pulmonaire)

Chen JY, Lien HC, Chen JS, Chang YC

An incidental pulmonary part-solid ground-glass nodule in a patient under anticoagulant therapy.

Thorax 2016 Jan;71;94-5 — 2016 Jan — 94-5

Kaira K, Takei Y, Matsuura M, Saito R

Pulmonary hematoma resulting from anticoagulant therapy.

AJR. American journal of roentgenology 2003 Jun;180;1740 — 2003 Jun — 1740

Chakraborty AK, Dreisin RB

Pulmonary hematoma secondary to anticoagulant therapy.

Annals of internal medicine 1982 Jan;96;67-9 — 1982 Jan — 67-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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