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The Drug-Induced Respiratory Disease Website

See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812

Publications

Breton JL, Garnier G, Toulouse J, Depierre A

Bronchoalveolar lavage and gold salt-induced pneumonitis.

Chest 1985 Mar;87;410 — 1985 Mar — 410

McFadden RG, Fraher LJ, Thompson JM

Gold-naproxen pneumonitis. A toxic drug interaction?

Chest 1989 Jul;96;216-8 — 1989 Jul — 216-8