The Drug-Induced Respiratory Disease Website

Imatinib

Pulmonary edema, cardiogenic

(Fr: OAP cardiogénique). Can result from left or biventricular dysfunction/failure. See also under XIIa, XIId, XIIai

Ran HH, Zhang R, Lu XC, Yang B, Fan H, Zhu HL

Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review.

Journal of geriatric cardiology : JGC 2012 Dec;9;411-4 — 2012 Dec — 411-4

Pulido EG, Riquelme A, Ballesteros J, Vaz MÁ

Congestive heart failure in a 77-year-old woman receiving adjuvant treatment with imatinib for a large gastric gastrointestinal stromal tumour.

Anti-cancer drugs 2012 Jun;23 Suppl;S15-7 — 2012 Jun — S15-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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