The Drug-Induced Respiratory Disease Website

Anthracyclines

Cardiomyopathy (acute, subacute, chronic)

See PMID 9744975, 23514294, 25948399

Sawyer DB

Anthracyclines and heart failure.

The New England journal of medicine 2013 Mar 21;368;1154-6 — 2013 Mar 21 — 1154-6

Singal PK, Iliskovic N

Doxorubicin-induced cardiomyopathy.

The New England journal of medicine 1998 Sep 24;339;900-5 — 1998 Sep 24 — 900-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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