The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Eye-catcher: Tongue edema

Bramante RM, Rand M

Images in clinical medicine. Angioedema.

The New England journal of medicine 2011 Jul 14;365;e4 — 2011 Jul 14 — e4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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