The Drug-Induced Respiratory Disease Website

Cardiovascular collapse - Cardiogenic shock - Hypotension

Particularly in those patients exposed to ACE inhibitor drugs

Kalra A, Palaniswamy C, Patel R, Kalra A, Selvaraj DR

Acute hypotensive transfusion reaction with concomitant use of angiotensin-converting enzyme inhibitors: a case report and review of the literature.

American journal of therapeutics 2012 Mar;19;e90-4 — 2012 Mar — e90-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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