The Drug-Induced Respiratory Disease Website

Cocaine

Takotsubo (stress) cardiomyopathy

Cases have also been described following drug overdose (PMID 25172356) or withdrawal (24170890)

Sarkar S, Arguelles E, de Elia C

Takosubo cardiomyopathy presenting as a non-ST segment elevation myocardial infarction in the setting of cocaine use and asthma exacerbation.

International journal of cardiology 2013 Sep 20;168;e1-2 — 2013 Sep 20 — e1-2

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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