The Drug-Induced Respiratory Disease Website

Adalimumab

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

ILD cases that occurred with combo treatments (methotrexate + adalimumab) (e.g. PMID 24626274) are not included due un uncertain causality

Allanore Y, Devos-François G, Caramella C, Boumier P, Jounieaux V, Kahan A

Fatal exacerbation of fibrosing alveolitis associated with systemic sclerosis in a patient treated with adalimumab.

Annals of the rheumatic diseases 2006 Jun;65;834-5 — 2006 Jun — 834-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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