The Drug-Induced Respiratory Disease Website

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Tests to document AERD at PMID 17521312. Induction of tolerance/desensitization at PMID 23861151, 24369807

Ameratunga R, Randall N, Dalziel S, Anderson BJ

Samter's triad in childhood: a warning for those prescribing NSAIDs.

Paediatric anaesthesia 2013 Aug;23;757-9 — 2013 Aug — 757-9

Picado C, Castillo JA, Montserrat JM, Agusti-Vidal A

Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation.

The European respiratory journal 1989 Feb;2;127-9 — 1989 Feb — 127-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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