The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Anai S, Nakayama Y, Gushiken H, Chinen S, Masuda K, Kamiya H, Ueno S, Maeda M, Kiyuna M, Sato Y, Matsumoto T
Diffuse alveolar hemorrhage and acute eosinophilic pneumonia: A rare form of amiodarone pulmonary toxicity diagnosed by bronchoalveolar lavage.
Journal of cardiology cases 2023 Mar;27;93-96 — 2023 Mar — 93-96
Case report of amiodarone-associated allergic pneumonitis amidst the COVID-19 pandemic.
Reviews in cardiovascular medicine 2021 03 30;22;181-184 — 2021 03 30 — 181-184
Eosinophilic pneumonia: A rare manifestation of amiodarone toxicity diagnosed using traditional bronchoscopy.
Respiratory medicine case reports 2019;27;100856 — 2019 — 100856
Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.
The American journal of surgical pathology 2012 Apr;36;509-16 — 2012 Apr — 509-16