The Drug-Induced Respiratory Disease Website

Etoposide

Cardiovascular collapse - Cardiogenic shock - Hypotension

See also under Xf and XIIe, , f, g, k, l, o, s, t, ad, ag

Cersosimo RJ, Calarese P, Karp DD

Acute hypotensive reaction to etoposide with successful rechallenge: case report and review of the literature.

DICP : the annals of pharmacotherapy 1989 Nov;23;876-7 — 1989 Nov — 876-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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