The Drug-Induced Respiratory Disease Website

Anticonvulsants-Anticonvulsivants

Subclinical ANA positivity

(ANA : Antinuclear antibodies). Subclinical organ damage or dysfuction should be investigated. See also under Xd and Xe

Singsen BH, Fishman L, Hanson V

Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants.

Pediatrics 1976 Apr;57;529-34 — 1976 Apr — 529-34

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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