The Drug-Induced Respiratory Disease Website

Beta-blockers

Subclinical ANA positivity

(ANA : Antinuclear antibodies). Subclinical organ damage or dysfuction should be investigated. See also under Xd and Xe

Booth RJ, Wilson JD, Bullock JY

Beta-adrenergic-receptor blockers and antinuclear antibodies in hypertension.

Clinical pharmacology and therapeutics 1982 May;31;555-8 — 1982 May — 555-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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