The Drug-Induced Respiratory Disease Website

Phenacetin

Sulfhemoglobinemia

Known from the 1940s (PMID 18883450)

Millar J, Péloquin R, De Leeuw NK

Phenacetin-induced hemolytic anemia.

Canadian Medical Association journal 1972 Apr 08;106;770-5 — 1972 Apr 08 — 770-5

Schmitter CR

Sulfhemoglobinemia and methemoglobinemia--uncommon causes of cyanosis.

Anesthesiology 1975 Nov;43;586-7 — 1975 Nov — 586-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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