The Drug-Induced Respiratory Disease Website

Sulfamides - Sulfonamides

Sulfhemoglobinemia

Known from the 1940s (PMID 18883450)

BRANDENBURG RO, SMITH HL

Sulfhemoglobinemia; a study of 62 clinical cases.

American heart journal 1951 Oct;42;582-8 — 1951 Oct — 582-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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