The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Fatal noncardiogenic pulmonary edema related to nonionic, iso-osmolar iodine contrast medium: one case report.
BMC pulmonary medicine 2022 Mar 31;22;118 — 2022 Mar 31 — 118
Acute pulmonary edema induced by non-ionic low-osmolar radiographic contrast media.
Open access emergency medicine : OAEM 2018;10;75-79 — 2018 — 75-79
[Pulmonary oedema subsequent to radiographic contrast in a computed tomography of the coronary arteries].
Ugeskrift for laeger 2012 May 07;174;1316-7 — 2012 May 07 — 1316-7
Case reports of death after nonionic iodine contrast medium injection during spiral computed tomography scan performed for suspected pulmonary embolism.
The American journal of emergency medicine 2006 Jul;24;497-9 — 2006 Jul — 497-9
Review article: Effects of radiographic contrast media on the lung.
The British journal of radiology 2003 May;76;290-5 — 2003 May — 290-5
Fatal non-cardiogenic pulmonary oedema after intravenous non-ionic radiographic contrast.
Lancet (London, England) 2002 Mar 23;359;1037-8 — 2002 Mar 23 — 1037-8
Pulmonary edema following intravenous injection of nonionic low-osmolar contrast medium--appearance on HRCT. A case report.
Acta radiologica (Stockholm, Sweden : 1987) 1998 Jan;39;81-3 — 1998 Jan — 81-3
Non-cardiogenic pulmonary oedema after intravenous administration of non-ionic contrast media.
Acta radiologica (Stockholm, Sweden : 1987) 1996 Sep;37;823-5 — 1996 Sep — 823-5
Noncardiogenic pulmonary edema induced by nonionic low-osmolality radiographic contrast media.
The Journal of allergy and clinical immunology 1995 Nov;96;698-9 — 1995 Nov — 698-9
Non-cardiogenic pulmonary edema following intravenous pyelography.
Connecticut medicine 1982 Apr;46;180-2 — 1982 Apr — 180-2
Radiographic contrast media-induced noncardiogenic pulmonary edema: case report and review of the literature.
The Journal of allergy and clinical immunology 1984 Jul;74;104-7 — 1984 Jul — 104-7
Retinal embolism after hysterosalpingography.
The British journal of ophthalmology 1973 Mar;57;166-9 — 1973 Mar — 166-9
Noncardiogenic pulmonary edema resulting from intravascular administration of contrast material.
AJR. American journal of roentgenology 1991 Aug;157;255-6 — 1991 Aug — 255-6
Noncardiogenic pulmonary edema associated with intravenous radiocontrast administration.
Chest 1992 Aug;102;620-1 — 1992 Aug — 620-1
Shock lung with massive tracheal loss of plasma.
JAMA 1977 Jun 06;237;2511-3 — 1977 Jun 06 — 2511-3