The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Cough syncope

See also under IVd, IVe. Review on cough syncope on PMID 24238768

Jayarajan A, Prakash O

Cough syncope induced by enalapril.

Chest 1993 Jan;103;327-8 — 1993 Jan — 327-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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