The Drug-Induced Respiratory Disease Website

Acebutolol

Subclinical ANA positivity

(ANA : Antinuclear antibodies). Subclinical organ damage or dysfuction should be investigated. See also under Xd and Xe

Bloomquist JN, Laddu A, Engler R

Adverse effects of acebutolol in chronic stable angina: drug-induced positive antinuclear antibody.

Journal of cardiovascular pharmacology 1984 Sep-Oct;6;735-8 — 1984 Sep-Oct — 735-8

Booth RJ, Wilson JD, Bullock JY

Beta-adrenergic-receptor blockers and antinuclear antibodies in hypertension.

Clinical pharmacology and therapeutics 1982 May;31;555-8 — 1982 May — 555-8

Booth RJ, Bullock JY, Wilson JD

Antinuclear antibodies in patients on acebutolol.

British journal of clinical pharmacology 1980 May;9;515-7 — 1980 May — 515-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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