The Drug-Induced Respiratory Disease Website

Lidocaine (lignocaine, xylocaine)

Cyanosis, a low SpO2 and normal measured PaO2

See under XIVa: Methemoglobinemia

Kwok S, Fischer JL, Rogers JD

Benzocaine and lidocaine induced methemoglobinemia after bronchoscopy: a case report.

Journal of medical case reports 2008 Jan 23;2;16 — 2008 Jan 23 — 16

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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