The Drug-Induced Respiratory Disease Website

Clopidogrel

Hemopericardium - Bloody pericardial effusion

Large effusions can cause cardiac tamponade. May occur late into treatment with anticoagulants

Boulé S, Marquié C, Vanesson-Bricout C, Kouakam C, Brigadeau F, Guédon-Moreau L, Acheré C, Goéminne-Boulé C, Lacroix D, Klug D, Kacet S

Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.

Pacing and clinical electrophysiology : PACE 2012 May;35;605-11 — 2012 May — 605-11

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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