The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
New-onset bronchial asthma induced by low-dose amiodarone.
The Annals of pharmacotherapy 2005 Feb;39;385-6 — 2005 Feb — 385-6
Imamura H, Kinoshita O, Maruyama K, Izawa A, Uchikawa SI, Kumazaki S, Takahashi W, Yokoseki O, Yazaki Y, Koizumi T, Kubo K
Two cases of bronchial asthma after treatment with amiodarone.
Pacing and clinical electrophysiology : PACE 2001 Oct;24;1563-5 — 2001 Oct — 1563-5
Exacerbation of bronchial asthma following treatment with amiodarone. Demonstration of an antiadrenergic effect in vitro.
Chest 1984 Sep;86;492-4 — 1984 Sep — 492-4