The Drug-Induced Respiratory Disease Website

Amantadine

Pulmonary edema, noncardiogenic (NCPE)

The case by Cattoni et al. was associated with amantadine overdose

Cattoni J, Parekh R

Acute respiratory distress syndrome: A rare presentation of amantadine toxicity.

The American journal of case reports 2014;15;1-3 — 2014 — 1-3

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.