The Drug-Induced Respiratory Disease Website
Hypersensitivity and infusion reactions. May mimic systemic vasculitis (PMID 30746133). See also under 'Anaphylaxis' (Xf). Hypersensitivity reactions include the rapid development of malaise, cough, dyspnea, wheezing-bronchospasm, cutaneous rash, itching and pruritus. These symptoms may annunciate the onset of anaphylaxis (see Xf) especially if the drug is continued or the patient is inadvertenly rechallenged with the drug. Desensitization can be offered (PMID 26895621), so that patients can receive full treatment courses and need not be switched to an alternative, potentially more toxic or inferior therapy. See PMID 12634903, 12721396, 22149339, 22987983. Skin manifestations at PMID 24820798
Publications
Azathioprine hypersensitivity syndrome: report of two cases.
BMJ case reports 2021 May 19;14; — 2021 May 19
Azathioprine hypersensitivity syndrome in anti-myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis.
Clinical kidney journal 2019 Feb;12;89-91 — 2019 Feb — 89-91
Azathioprine Hypersensitivity Syndrome in a Cohort of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Patients.
The journal of allergy and clinical immunology. In practice 2019 Mar;7;1004-1009 — 2019 Mar — 1004-1009
Azathioprine hypersensitivity syndrome: a case report.
Acta clinica Belgica 2013 May-Jun;68;223-4 — 2013 May-Jun — 223-4
Azathioprine hypersensitivity reaction in a patient with ulcerative colitis.
The Annals of pharmacotherapy 1998 Apr;32;425-8 — 1998 Apr — 425-8
Combination of amikacin and carbenicillin with or without cefazolin as empirical treatment of febrile neutropenic patients. The International Antimicrobial Therapy Project Group of the European Organization for Research and Treatment of Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1983 Oct;1;597-603 — 1983 Oct — 597-603