The Drug-Induced Respiratory Disease Website

Myopathy-Myositis-Polymyositis

Including acute myositis, rhabdomyolysis, a mimic of autoimmune anti-Jo1-positive polymyositis/dermato-polymyositis and necrotizing autoimmune myopathy. Respiratory muscles can be involved (PMID 12904161): see specifically under IXac, Xba

Publications

Tsai MH, Yang JH, Kung SL, Hsiao YP

Levamisole-induced myopathy and leukocytoclastic vasculitis: a case report and literature review.

Dermatologic therapy 2013 Nov-Dec;26;476-80 — 2013 Nov-Dec — 476-80

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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