The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Prevalence of pulmonary edema among the deceased cases with acute Methadone poisoning: A report from Iran.
Journal of research in pharmacy practice 2016 Oct-Dec;5;290-293 — 2016 Oct-Dec — 290-293
Winklhofer S, Surer E, Ampanozi G, Ruder T, Stolzmann P, Elliott M, Oestreich A, Kraemer T, Thali M, Alkadhi H, Schweitzer W
Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.
European radiology 2014 Jun;24;1276-82 — 2014 Jun — 1276-82
Extracorporeal membrane oxygenation as rescue therapy for methadone-induced pulmonary edema.
Pediatric emergency care 2011 Jul;27;633-4 — 2011 Jul — 633-4
[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].
Presse medicale (Paris, France : 1983) 2011 Apr;40;436-8 — 2011 Apr — 436-8
Toxicology and pathology of deaths related to methadone: retrospective review.
The Western journal of medicine 2000 Jan;172;11-4 — 2000 Jan — 11-4
Pulmonary edema and adult respiratory distress syndrome following methadone abuse.
The American review of respiratory disease 1973 Jun;107;1047-51 — 1973 Jun — 1047-51
Methadone pulmonary edema.
Chest 1973 Feb;63;275-6 — 1973 Feb — 275-6
Nonfatal pulmonary edema after "freebase" cocaine smoking.
The American review of respiratory disease 1987 Jul;136;179-81 — 1987 Jul — 179-81
Methadone-induced pulmonary edema.
Canadian Medical Association journal 1975 Nov 22;113;966-7 — 1975 Nov 22 — 966-7