Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

A common cause of fulminant respiratory failure in RA. Careful exclusion of Pneumocystis pneumonia is always necessary

Publications

Gökten DB, Mercan R

Methotrexate-Associated Hypersensitivity Pneumonitis After 15 Years of Use: A Case Report and Literature Review.

Mediterranean journal of rheumatology 2025 Jun;36;316-321 — 2025 Jun — 316-321

Liu YC, Tu YL, Wu RC, Huang JL, Yao TC

Life-threatening pneumonitis complicating low-dose methotrexate treatment for juvenile idiopathic arthritis in a child.

Pediatric emergency care 2014 Jun;30;415-7 — 2014 Jun — 415-7

D'Elia T

Methotrexate-induced pneumonitis: heterogeneity of bronchoalveolar lavage and differences between cancer and rheumatoid arthritis.

Inflammation & allergy drug targets 2014 Feb;13;25-33 — 2014 Feb — 25-33

Kakavas S, Balis E, Lazarou V, Kouvela M, Tatsis G

Respiratory failure due to infliximab induced interstitial lung disease.

Heart & lung : the journal of critical care 2013 Nov-Dec;42;480-2 — 2013 Nov-Dec — 480-2

Saigal S, Singh RK, Poddar B

Acute methotrexate toxicity presenting as multiorgan failure and acute pneumonitis: A rare case report.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2012 Oct;16;225-7 — 2012 Oct — 225-7

Sathi N, Chikura B, Kaushik VV, Wiswell R, Dawson JK

How common is methotrexate pneumonitis? A large prospective study investigates.

Clinical rheumatology 2012 Jan;31;79-83 — 2012 Jan — 79-83

Brechmann T, Heyer C, Schmiegel W

[Methotrexate-induced pneumonitis in a woman with Crohn's disease].

Deutsche medizinische Wochenschrift (1946) 2007 Aug;132;1759-62 — 2007 Aug — 1759-62

Müller KM, Einsfelder BM

[Drug-induced pulmonary damage].

Der Pathologe 2006 Feb;27;19-26 — 2006 Feb — 19-26

Lateef O, Shakoor N, Balk RA

Methotrexate pulmonary toxicity.

Expert opinion on drug safety 2005 Jul;4;723-30 — 2005 Jul — 723-30

Kinder AJ, Hassell AB, Brand J, Brownfield A, Grove M, Shadforth MF

The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse drug reactions.

Rheumatology (Oxford, England) 2005 Jan;44;61-6 — 2005 Jan — 61-6

Arakawa H, Yamasaki M, Kurihara Y, Yamada H, Nakajima Y

Methotrexate-induced pulmonary injury: serial CT findings.

Journal of thoracic imaging 2003 Oct;18;231-6 — 2003 Oct — 231-6

Kramer N, Chuzhin Y, Kaufman LD, Ritter JM, Rosenstein ED

Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis.

Arthritis and rheumatism 2002 Dec 15;47;670-1 — 2002 Dec 15 — 670-1

Fuhrman C, Parrot A, Wislez M, Prigent H, Boussaud V, Bernaudin JF, Mayaud C, Cadranel J

Spectrum of CD4 to CD8 T-cell ratios in lymphocytic alveolitis associated with methotrexate-induced pneumonitis.

American journal of respiratory and critical care medicine 2001 Oct 01;164;1186-91 — 2001 Oct 01 — 1186-91

Zisman DA, McCune WJ, Tino G, Lynch JP

Drug-induced pneumonitis: the role of methotrexate.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2001 Oct;18;243-52 — 2001 Oct — 243-52

Imokawa S, Colby TV, Leslie KO, Helmers RA

Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients.

The European respiratory journal 2000 Feb;15;373-81 — 2000 Feb — 373-81

Ohosone Y, Okano Y, Kameda H, Fujii T, Hama N, Hirakata M, Mimori T, Akizuki M, Ikeda Y

Clinical characteristics of patients with rheumatoid arthritis and methotrexate induced pneumonitis.

The Journal of rheumatology 1997 Dec;24;2299-303 — 1997 Dec — 2299-303

Cannon GW

Methotrexate pulmonary toxicity.

Rheumatic diseases clinics of North America 1997 Nov;23;917-37 — 1997 Nov — 917-37

Kremer JM, Alarcón GS, Weinblatt ME, Kaymakcian MV, Macaluso M, Cannon GW, Palmer WR, Sundy JS, St Clair EW, Alexander RW, Smith GJ, Axiotis CA

Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review.

Arthritis and rheumatism 1997 Oct;40;1829-37 — 1997 Oct — 1829-37

Alarcón GS, Kremer JM, Macaluso M, Weinblatt ME, Cannon GW, Palmer WR, St Clair EW, Sundy JS, Alexander RW, Smith GJ, Axiotis CA

Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group.

Annals of internal medicine 1997 Sep 01;127;356-64 — 1997 Sep 01 — 356-64

Salaffi F, Manganelli P, Carotti M, Subiaco S, Lamanna G, Cervini C

Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.

Clinical rheumatology 1997 May;16;296-304 — 1997 May — 296-304

Barrera P, Laan RF, van Riel PL, Dekhuijzen PN, Boerbooms AM, van de Putte LB

Methotrexate-related pulmonary complications in rheumatoid arthritis.

Annals of the rheumatic diseases 1994 Jul;53;434-9 — 1994 Jul — 434-9

Whitcomb ME, Schwarz MI, Tormey DC

Methotrexate pneumonitis: case report and review of the literature.

Thorax 1972 Sep;27;636-9 — 1972 Sep — 636-9

Shapiro CL, Yeap BY, Godleski J, Jochelson MS, Shipp MA, Skarin AT, Canellos GP

Drug-related pulmonary toxicity in non-Hodgkin's lymphoma. Comparative results with three different treatment regimens.

Cancer 1991 Aug 15;68;699-705 — 1991 Aug 15 — 699-705

Hargreaves MR, Mowat AG, Benson MK

Acute pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis: report of five cases and review of published reports.

Thorax 1992 Aug;47;628-33 — 1992 Aug — 628-33

Manni JJ, Van den Broek P

Pulmonary complications of methotrexate therapy.

Clinical otolaryngology and allied sciences 1977 May;2;131-7 — 1977 May — 131-7

Lascari AD, Strano AJ, Johnson WW, Collins JG

Methotrexate-induced sudden fatal pulmonary reaction.

Cancer 1977 Oct;40;1393-7 — 1977 Oct — 1393-7