The Drug-Induced Respiratory Disease Website

Amiodarone

Pleural thickening - Fibrothorax

With this drug, pleural thickening tends to be most prominent 'en face' the areas of pulmonary shadowing

Vernhet H, Bousquet C, Durand G, Giron J, Senac JP

Reversible amiodarone-induced lung disease: HRCT findings.

European radiology 2001;11;1697-703 — 2001 — 1697-703

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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