The Drug-Induced Respiratory Disease Website

Calcium channel blockers

Pulmonary edema, noncardiogenic (NCPE)

A complication of drug overdose

Afzal MA, Ozgur SS, Tagliaferri AR, Bathobakae L, Shamoon F

Unique Case of Cardiogenic Shock in the Setting of Cumulative Calcium Channel Blocker Toxicity.

Cureus 2023 Mar;15;e36762 — 2023 Mar — e36762

Chaouat A, Kessler R, Weitzenblum E

Pulmonary oedema and pleural effusion in two patients with primary pulmonary hypertension treated with calcium channel blockers.

Heart (British Cardiac Society) 1996 Apr;75;383 — 1996 Apr — 383

Howarth DM, Dawson AH, Smith AJ, Buckley N, Whyte IM

Calcium channel blocking drug overdose: an Australian series.

Human & experimental toxicology 1994 Mar;13;161-6 — 1994 Mar — 161-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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