Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812

Publications

Dias OM, Nascimento ECTD, Chate RC, Kairalla RA, Baldi BG

Eosinophilic pneumonia: remember topical drugs as a potential etiology.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2018 Nov-Dec;44;522-524 — 2018 Nov-Dec — 522-524

Klerkx S, Pat K, Wuyts W

Minocycline induced eosinophilic pneumonia: case report and review of literature.

Acta clinica Belgica 2009 Jul-Aug;64;349-54 — 2009 Jul-Aug — 349-54

Ono E, Miyazaki E, Matsuno O, Nureki S, Okubo T, Ando M, Kumamoto T

Minocycline-induced acute eosinophilic pneumonia: controversial results of lymphocyte stimulation test and re-challenge test.

Internal medicine (Tokyo, Japan) 2007;46;593-5 — 2007 — 593-5

Roca B, Calvo B, Ferrer D

Minocycline hypersensitivity reaction with acute respiratory distress syndrome.

Intensive care medicine 2003 Feb;29;338 — 2003 Feb — 338

Nakano K, Gemma H, Ono T, Ito I, Chida K, Nakamura H

[A case of minocycline-induced eosinophilic pneumonia presenting with multiple white eosinophilic plaques in the tracheobronchial mucosa].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2001 Jan;39;24-9 — 2001 Jan — 24-9

Piette AM, Ramanoelina J, Gepner P, Larroche C, Blétry O

[Systemic reaction induced my minocycline treatment: a report of four patients and a review of the literature].

La Revue de medecine interne 1999 Oct;20;869-74 — 1999 Oct — 869-74

Hara H, Fujitsuka A, Morishima C, Kurihara N, Yamaguchi Z, Morishima T

Severe drug-induced pneumonitis associated with minocycline and nicotinamide therapy of a bullous pemphigoid.

Acta dermato-venereologica 1998 Sep;78;393-4 — 1998 Sep — 393-4

Toyoshima M, Sato A, Hayakawa H, Taniguchi M, Imokawa S, Chida K

A clinical study of minocycline-induced pneumonitis.

Internal medicine (Tokyo, Japan) 1996 Mar;35;176-9 — 1996 Mar — 176-9

Bando T, Fujimura M, Noda Y, Hirose J, Ohta G, Matsuda T

Minocycline-induced pneumonitis with bilateral hilar lymphadenopathy and pleural effusion.

Internal medicine (Tokyo, Japan) 1994 Mar;33;177-9 — 1994 Mar — 177-9

Sitbon O, Bidel N, Dussopt C, Azarian R, Braud ML, Lebargy F, Fourme T, de Blay F, Piard F, Camus P

Minocycline pneumonitis and eosinophilia. A report on eight patients.

Archives of internal medicine 1994 Jul 25;154;1633-40 — 1994 Jul 25 — 1633-40