The Drug-Induced Respiratory Disease Website
See PMID 30075570. Review at PMID 28291095. Major risk is UAO, with consequent asphyxia. Can be followed by irreversible hypoxic brain damage/death. See also under VIIIg. May occur in isolation or accompany drug-induced anaphylaxis. Airway angioedema can be in the form of acute swelling of the lips, tongue, mouth floor, uvula, pharynx, larynx, glottis, subglottic area and/or upper trachea. This can cause acute upper airway obstruction (UAO) and asphyxia. May overlap with IVb. Expedient identification the airway by endoscopy and maintenance of airway patency are crucially important, as if the UAO progresses emergent risky tracheostomy can be required. Icatibant may alleviate all manifestations of drug-induced angioedema (PMID: 22936825). Rebound phenomenon can occur after an initial falsely reassuring period of improvement. NPPE (IIg) may occur as a secondary complication. Reviews and series at PMID 20447725, 20667117, 20922352, 22552531, 22936825, 22976464, 25059449. Angioedema can also involve the bowel wall in concomitance, causing abdominal pain or cramping or simulate an acute abdomen (PMID: 20376210, 21785085, 22867837)
Publications
A real-world pharmacovigilance analysis of adverse events associated with irbesartan using the FAERS and JADER databases.
Frontiers in pharmacology 2024;15;1485190 — 2024 — 1485190
Angiotensin-converting Enzyme Inhibitor Angioedema Requiring Admission to an Intensive Care Unit.
The American journal of medicine 2015 Jul;128;785-9 — 2015 Jul — 785-9
Treatment of angiotensin receptor blocker-induced angioedema: A case series.
The Laryngoscope 2015 Jul;125;1619-23 — 2015 Jul — 1619-23
Side effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists: are we facing a new syndrome.
The American journal of cardiology 2012 Nov 15;110;1552-3 — 2012 Nov 15 — 1552-3