The Drug-Induced Respiratory Disease Website

Cocaine

Pulmonary arterial hypertension

Via the levamisole cutting agent

Alzghoul BN, Abualsuod A, Alqam B, Innabi A, Palagiri DR, Gheith Z, Amer FN, Meena NK, Kenchaiah S

Cocaine Use and Pulmonary Hypertension.

The American journal of cardiology 2020 01 15;125;282-288 — 2020 01 15 — 282-288

Karch SB, Defraia B, Messerini L, Mari F, Vaiano F, Bertol E

Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user.

Forensic science international 2014 Jul;240;e7-10 — 2014 Jul — e7-10

Yakel DL, Eisenberg MJ

Pulmonary artery hypertension in chronic intravenous cocaine users.

American heart journal 1995 Aug;130;398-9 — 1995 Aug — 398-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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