The Drug-Induced Respiratory Disease Website

Aprotinin

Cardiovascular collapse - Cardiogenic shock - Hypotension

See also under Xf and XIIe, , f, g, k, l, o, s, t, ad, ag

Lango R, Kowalik MM, Klajbor K, Pawlaczyk R, Musia?-Swiatkiewicz V, Rogowski J

High-volume hemofiltration as rescue therapy for refractory shock after inadvertent rapid aprotinin administration.

Journal of cardiothoracic and vascular anesthesia 2009 Aug;23;526-8 — 2009 Aug — 526-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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