The Drug-Induced Respiratory Disease Website

Dasatinib

Imaging: Pleural effusion

Bergeron A, Réa D, Levy V, Picard C, Meignin V, Tamburini J, Bruzzoni-Giovanelli H, Calvo F, Tazi A, Rousselot P

Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series.

American journal of respiratory and critical care medicine 2007 Oct 15;176;814-8 — 2007 Oct 15 — 814-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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