The Drug-Induced Respiratory Disease Website

Aminophylline

Myocarditis (can be fulminate/fulminant)

Typically acute. Can be fulminate/fulminant and fatal (PMID 30242316). General review at PMID 28540649. Recent addition to the lst of causal drugs include immune checkpoint inhibitors (PMID 28833116, 29801747)

Publications

Starakis I, Starakis I, Lekkou A, Blikas A, Labropoulou-Karatza C

Drug-induced cardiotoxicity due to aminophylline treatment: a case report.

Current therapeutic research, clinical and experimental 2003 Jun;64;367-74 — 2003 Jun — 367-74

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

LATEST CHANGELOG

No activity has been recorded yet.

View full changelog