The Drug-Induced Respiratory Disease Website

Amiodarone

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Tziatzios GD, Didagelos M, Tziatzios I, Hadjimiltiades S, Karamitsos T

Torsades de Pointes and Prolonged Self-Terminating Ventricular Fibrillation Induced by Amiodarone.

Cureus 2020 Nov 25;12;e11693 — 2020 Nov 25 — e11693

Han D, Tan H, Sun C, Li G

Amiodarone-induced life-threatening torsade de pointes in an end-stage lung cancer patient receiving gefitinib.

Oxford medical case reports 2019 Jan;2019;omy122 — 2019 Jan — omy122

Brooks MJ, Pattison DA, Teo EP, Price S, Gurvitch R

Amiodarone-induced destructive thyroiditis associated with coronary artery vasospasm and recurrent ventricular fibrillation.

European thyroid journal 2013 Mar;2;65-7 — 2013 Mar — 65-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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