The Drug-Induced Respiratory Disease Website

Dasatinib

Pulmonary alveolar proteinosis (PAP)

(Fr: aspect de protéinose alvéolaire). Drugs are a rare cause of PAP pattern. See under XV

Yoshimura M, Kojima K, Tomimasu R, Fukushima N, Hayashi S, Sueoka E, Kimura S

ABL tyrosine kinase inhibitor-induced pulmonary alveolar proteinosis in chronic myeloid leukemia.

International journal of hematology 2014 Dec;100;611-4 — 2014 Dec — 611-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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