The Drug-Induced Respiratory Disease Website

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Aggarwal N, Kupfer Y, Chawla K, Tessler S

Altered mental status and complete heart block: an unusual presentation of aspirin toxicity.

BMJ case reports 2013 Jun 10;2013; — 2013 Jun 10

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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