The Drug-Induced Respiratory Disease Website

Aluminum phosphide

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Mohan B, Gupta V, Ralhan S, Gupta D, Puri S, Wander GS, Singh B

Role of Extracorporeal Membrane Oxygenation in Aluminum Phosphide Poisoning-Induced Reversible Myocardial Dysfunction: A Novel Therapeutic Modality.

The Journal of emergency medicine 2015 Nov;49;651-6 — 2015 Nov — 651-6

Elabbassi W, Chowdhury MA, Fachtartz AA

Severe reversible myocardial injury associated with aluminium phosphide toxicity: A case report and review of literature.

Journal of the Saudi Heart Association 2014 Oct;26;216-21 — 2014 Oct — 216-21

Jadhav AP, Nusair MB, Ingole A, Alpert MA

Unresponsive ventricular tachycardia associated with aluminum phosphide poisoning.

The American journal of emergency medicine 2012 May;30;633.e3-5 — 2012 May — 633.e3-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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