The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Pulmonary edema after naloxone administration for opioid reversal: a systematic review of case reports and causality assessment using the Naranjo scale.
Clinical toxicology (Philadelphia, Pa.) 2024 May;62;334-342 — 2024 May — 334-342
Non-Cardiogenic Pulmonary and Peripheral Edema as an Untoward Reaction of Naloxone.
Journal of addictions nursing 2024 Apr-Jun 01;35;114 — 2024 Apr-Jun 01 — 114
The Double-Edged Sword: Naloxone-Induced Noncardiogenic Pulmonary Edema.
Cureus 2023 Jul;15;e41642 — 2023 Jul — e41642
Naloxone-associated pulmonary edema following recreational opioid overdose: A case series.
The American journal of emergency medicine 2021 Dec 17;53;41-43 — 2021 Dec 17 — 41-43
Naloxone-Induced Acute Pulmonary Edema is Dose-Dependent: A Case Series.
The American journal of case reports 2021 Mar 17;22;e929412 — 2021 Mar 17 — e929412
Naloxone induced pulmonary edema.
Journal of community hospital internal medicine perspectives 2021 Jan 26;11;139-142 — 2021 Jan 26 — 139-142
Naloxone-Induced Non-Cardiogenic Pulmonary Edema: A Case Report.
Drug safety - case reports 2018 May 10;5;20 — 2018 May 10 — 20
[Naloxone-induced pulmonary edema. Case report with review of the literature and critical evaluation].
Der Anaesthesist 2012 Feb;61;129-36 — 2012 Feb — 129-36
Naloxone-induced pulmonary edema: a potential cause of postoperative morbidity in laparoscopic donor nephrectomy.
Indian journal of medical sciences 2009 Feb;63;72-5 — 2009 Feb — 72-5
Naloxone--for intoxications with intravenous heroin and heroin mixtures--harmless or hazardous? A prospective clinical study.
Journal of toxicology. Clinical toxicology 1996;34;409-16 — 1996 — 409-16
Acute pulmonary edema in healthy teenagers following conservative doses of intravenous naloxone.
Anesthesiology 1984 May;60;485-6 — 1984 May — 485-6
Pulmonary edema following naloxone administration in a patient without heart disease.
Anesthesiology 1983 Dec;59;576-7 — 1983 Dec — 576-7
Pulmonary edema following low-dose naloxone administration.
Anesthesiology 1986 Dec;65;709-10 — 1986 Dec — 709-10
Naloxone-induced pulmonary edema.
Annals of emergency medicine 1987 Nov;16;1294-6 — 1987 Nov — 1294-6
Two cases of naloxone-induced pulmonary oedema--the possible use of phentolamine in management.
Anaesthesia and intensive care 1991 Nov;19;578-80 — 1991 Nov — 578-80
Acute pulmonary edema following naloxone reversal of high-dose morphine anesthesia.
Anesthesiology 1977 Oct;47;376-8 — 1977 Oct — 376-8