The Drug-Induced Respiratory Disease Website

Catheter ablation for atrial fibrillation

Major/massive hemoptysis

Can be fatal from blood loss, or clotting in the central airway causing acute airway compromise and respiratory failure

Matsumoto S, Suzuki M, Matsubayashi S, Tsukada A, Kusaba Y, Katsuno T, Iikura M, Izumi S, Takeda Y, Hojo M, Sugiyama H

Refractory Hemoptysis Caused by Severe Pulmonary Vein Stenosis after Multiple Catheter Ablations.

Internal medicine (Tokyo, Japan) 2021;60;3279-3284 — 2021 — 3279-3284

Lee JY, Chon GR, Park JH, Kang BJ, Shim TS, Jo KW

Massive hemoptysis due to pulmonary vein stenosis following catheter ablation for atrial fibrillation.

Respiratory care 2015 Mar;60;e52-5 — 2015 Mar — e52-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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