The Drug-Induced Respiratory Disease Website

Cocaine

Pneumopericardium

Can be associated with or result from pneumomediastinum

Galloo X, Stroobants J, Yeo D, El-Abdellati E

Cocaine-Induced Pneumopericardium: Safe for Discharge? A Case Report and Literature Review.

Case reports in cardiology 2019;2019;4107815 — 2019 — 4107815

Albrecht CA, Jafri A, Linville L, Anderson HV

Cocaine-induced pneumopericardium.

Circulation 2000 Nov 28;102;2792-4 — 2000 Nov 28 — 2792-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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