The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Severe asthma induced by naproxen--a case report and review of the literature.
Annals of allergy 1980 Dec;45;372-5 — 1980 Dec — 372-5
Severe asthma after naproxen.
Lancet (London, England) 1987 May 30;1;1270 — 1987 May 30 — 1270
Asthmatic attacks induced in aspirin-sensitive patients by diclofenac and naproxen.
British medical journal 1977 Jul 23;2;231-2 — 1977 Jul 23 — 231-2