The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Nitrofurantoin-induced pulmonary toxicity: A case report and review of the literature.
Journal of infection and public health 2015 Jul-Aug;8;309-13 — 2015 Jul-Aug — 309-13
Nitrofurantoin: cause of DRESS syndrome.
BMJ case reports 2013 May 08;2013; — 2013 May 08
Nitrofurantoin-induced immune-mediated lung and liver disease.
Vojnosanitetski pregled 2012 Jun;69;536-40 — 2012 Jun — 536-40
Chronic eosinophilic pneumonia secondary to long-term use of nitrofurantoin: high-resolution computed tomography findings.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2008 Mar;34;181-4 — 2008 Mar — 181-4
[Drug-induced eosinophilic pneumonia].
Der Nervenarzt 2008 Jun;79;696-8 — 2008 Jun — 696-8
Baptista JP, Casanova PC, Sousa JP, Martins PJ, Simões A, Fernandes V, Souto J, Costa JJ, Rebelo A, Carvalho L, Pimentel J
[Acute eosinophilic pneumonia associated with acute respiratory distress syndrome: case report].
Revista portuguesa de pneumologia 2004 Jul-Aug;10;355-64 — 2004 Jul-Aug — 355-64
Two unusual pathological reactions to nitrofurantoin: case reports.
Histopathology 1986 Jul;10;701-6 — 1986 Jul — 701-6