The Drug-Induced Respiratory Disease Website

Benzodiazepines

Deterioration/exacerbation of preexisting asthma or COPD

Not all studies confirmed that (See PMID 24482539)

Vozoris NT, Fischer HD, Wang X, Stephenson AL, Gershon AS, Gruneir A, Austin PC, Anderson GM, Bell CM, Gill SS, Rochon PA

Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD.

The European respiratory journal 2014 Aug;44;332-40 — 2014 Aug — 332-40

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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