The Drug-Induced Respiratory Disease Website

Adrenaline (epinephrine)

Torsades de pointe

See under PMID 35012678

Cubeddu LX

Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Current cardiology reviews 2009 Aug;5;166-76 — 2009 Aug — 166-76

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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