The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Adverse reactions to nitrofurantoin in the United Kingdom, Sweden, and Holland.
British medical journal (Clinical research ed.) 1982 May 15;284;1440-2 — 1982 May 15 — 1440-2
Asthma associated with the use of nitrofurantoin.
Canadian Medical Association journal 1966 Jan 01;94;40-1 — 1966 Jan 01 — 40-1
Allergic tracheobronchitis due to nitrofurantoin sensitivity. Report of a case.
Diseases of the chest 1965 Oct;48;429-30 — 1965 Oct — 429-30
Nitrofurantoin pulmonary hypersensitivity.
The Medical journal of Australia 1970 Jul 18;2;136-9 — 1970 Jul 18 — 136-9
[Asthma and nitrofurantoin].
Revista clinica espanola 1979 Feb 15;152;235-7 — 1979 Feb 15 — 235-7