The Drug-Induced Respiratory Disease Website
The broad term 'cardiotoxicity' encompasses several entities and patterns of cardiac injury including subclinical change in LVEF or cardiac biomarkers, cardiomyopathy, heart failure, AV heart block, conduction abnormalities, myocarditis, myocardial fibrosis, dysrrhythmias, pericarditis, pericardial effusion, tamponade, syncope, cardiac/cardiopulmonary arrest and/or valvular heart dysfunction or disease. Pulmonary edema and pleural effusion may be the annunciating signs and symptoms of cardiotoxicity (PMID 1403060). Cardiotoxicity is a significant hurdle of novel anticancer agent use including the immune checkpoint inhibitors (PMID 25210198, 25574894, 27732808, 29912044, 29980467, 30433897). Can be life-threatening or fatal (PMID 29980467)
Publications
Clozapine Associated with Autoimmune Reaction, Fever and Low Level Cardiotoxicity - A Case Report.
In vivo (Athens, Greece) 2017 01 02;31;141-143 — 2017 01 02 — 141-143
Does a subclinical cardiotoxic effect of clozapine exist? Results from a follow-up pilot study.
Cardiovascular & hematological agents in medicinal chemistry 2012 Jun;10;148-53 — 2012 Jun — 148-53