The Drug-Induced Respiratory Disease Website
Lone, isolated, free-flowing pleural effusion on imaging. See other forms of pleural effusions under Vb, d, e, g, h, i, m which may present similarly on imaging. The effusion can be uni- or bilateral. More often a lymphocyte-, mixed or neutrophil-rich exudate. At times the effusion is eosipophil-rich. Pleural effusion can be present with the acute clinical phase of severe drug-induced ILD (e.g. methotrexate lung; PMID 16840219). In general, pleural effusion in the context of drug-induced ILD or pulmonary edema is not tabulated under this heading. ANA-panel indicated to diagnose drug-induced lupus PMID 10424528
Publications
Pleural effusion: An uncommon manifestation of nitrofurantoin-induced pulmonary injury.
Respiratory medicine case reports 2016;19;65-7 — 2016 — 65-7
Nitrofurantoin pulmonary toxicity: neglected threat.
Current drug safety 2010 Apr;5;125-8 — 2010 Apr — 125-8
Eosinophilic pleural effusions.
Current opinion in pulmonary medicine 2003 Jul;9;254-60 — 2003 Jul — 254-60
Nitrofurantoin pneumonia.
JAMA 1967 Mar 06;199;765-6 — 1967 Mar 06 — 765-6
Lymphopenia in acute nitrofurantoin pleuropulmonary reactions.
The Journal of allergy and clinical immunology 1977 Jun;59;445-8 — 1977 Jun — 445-8