The Drug-Induced Respiratory Disease Website

Doxorubicin - Adriamycin

‘Cardiotoxicity’

Liposomal doxorubicin may be associated with lesser risk of cardiotoxicity (PMID 26204517)

Wallace KB

Doxorubicin-induced cardiac mitochondrionopathy.

Pharmacology & toxicology 2003 Sep;93;105-15 — 2003 Sep — 105-15

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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